I was born in Baskil in 1971. I completed my primary and secondary education in Baskil. I started my education at Çukurova University Faculty of Medicine in 1988. I graduated as a medical doctor in 1994. After completing my compulsory service in various health centers in Malatya, I started studying Internal Medicine at Malatya İnönü University Faculty of Medicine in 1998. I completed my Internal Medicine training in 2003. I started my subspecialty training at Malatya İnönü University, Department of Gastroenterology. In 2006, I completed my Gastroenterology training and started my compulsory service at Elazığ Training and Research Hospital. In 2010, he worked as an assistant professor in the Gastroenterology department of the Department of Internal Medicine at Fırat University. I started working as. In 2014, Assoc. I got the title. In 2019, Prof. I rose to the title. I left after working at the same institution for 2 years. As of 2021, I started working at Elazığ Private Eastern Anatolia Hospital by establishing the Gastroenterology clinic.

Supervised Master's Theses:
Supervised Doctoral Theses/Proficiency in Art Studies:

Demirel U., "Evaluation of the effects of conventional and conventional+Lactobacillus Reuteri treatment on visfatin, some cytokine levels and functional bowel disease severity index in patients diagnosed with Irritable Bowel Syndrome", Fırat University, 2012.
Demirel U., "Evaluation of the Correlation Between Gallbladder Stone Frequency and Hypersplenism Findings and Splenic Elastography Findings in Patients with Cirrhosis", Fırat University,
Demirel U. ''Investigation of IL28B gene polymorphism and gene expression in chronic hepatitis B patients'', Fırat University, 2013.

Duties Performed in Projects:

Administrative Duties:

Fırat University Faculty of Medicine Infection Control Committee Member
Memberships in Scientific Organizations: Turkish Gastroenterology Association

Awards:

National Gastroenterology Week (30 August-4 September 2005 Malatya) Best first poster award (E35).
National Gastroenterology Week (4-7 November 2006, Istanbul) Second best poster award (Danone Institute Association special award) (E42).
Hepato Gastroenterology Congress (29 September-3 October 2010, Antalya) Poster Presentation Second Prize (E51).
Hepato Gastroenterology Congress (28 September-02 October, Antalya) Oral Presentation First Prize (E62).

WORKS

Name and summary of the specialization thesis:

"Two findings of portal hypertension: correlation evaluation of serum acid albumin gradient and esophageal varices"
Summary: In determining the etiology of ascitic fluid, it has been shown in many studies conducted in recent years that the diagnostic value of classification as exudate or transudate according to the total protein level cannot exceed 55.6%. Another clinical disadvantage of this type of classification is that it is significantly affected by infection, diuretic use and paracentesis. Contrary to the traditional classification, it has been shown in many studies that the classification of acid fluid as portal hypertension related or unrelated to portal hypertension according to the serum-acid albumin gradient (SAAG) has an accuracy rate of up to 97% in adults, although it is relatively low in children in determining the etiological cause. It has also been shown that the classification made in this way is not affected by the presence of infection, diuretic use and paracentesis.

Most studies published in the literature include ascites patients with alcoholic cirrhosis. In this study, we evaluated the correlation between SAAG and esophageal varices, which are signs of portal hypertension, in patients with non-alcoholic cirrhosis. SAAG was above 1.1 in all our patients and was compatible with the 97% accuracy rate in studies published in the literature. No correlation was found between SAAG and the degree of esophageal varices. There was only a weak correlation between the degree of varicose veins and ascites albumin (p=0.01). It is noteworthy that all patients with SAAG have esophageal varices. The lack of sufficient studies in the literature on this subject and the small number of patients make it difficult to make further comments.

Although there is a correlation between LAAG and esophageal varices in a small number of non-alcoholic cirrhosis patients in the literature, our findings support the data in the literature. Although this correlation can be demonstrated in cases with alcoholic cirrhosis, there is no correlation in cases with non-alcoholic cirrhosis.

"Effects of gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats"
Summary: Purpose:Bacterial translocation (BT) has been established in the development of infectious complications in many serious clinical conditions such as fulminant liver failure (FHF). We aimed to investigate the effects of Gingko biloba (GB), vitamin E (Vit E) and melatonin on intestinal oxidative damage and bacterial translocation in thioacetamide (TAA)-induced PHF in rats. Materials and Methods: A total of 42 rats were divided into 5 groups. Group 1 (n=8) was the control group. Group 2 (n=10) was the TAA group, and the rats in this group received 350 mg/kg/day TAA intraperitoneally (ip) for 3 days. Oral 100 mg/kg/day GB to group 3 (n=8), orally 200 mg/kg/day Vit E to group 4 (n=8), 3 mg/day ip to group 5 (n=8). kg/day melatonin treatment was started 48 hours before the first TAA dose and continued for the next 5 days. Results: Severe hepatic and intestinal oxidative damage, increased Escherichia coli numbers in ileal aspirates, and higher CT frequencies were observed in the TAA group compared to the control group (all p's <0.001). Only GB treatment reduced hepatic oxidative damage (p<0.001). There was no difference between TAA and other antioxidant treatment groups in intestinal oxidative damage, E. Coli counts in ileal aspirates, and CT frequencies (p>0.05). Conclusion: Our results suggest that intestinal oxidative damage plays a role in the development of BT by disrupting the barrier function of the intestinal mucosa.

Articles published from the specialization thesis

U. Demirel, M. Karincaoglu, M. M. M. Harputluoğlu, M. Ates, Y. Seckin, B. Yildirim, F. Hilmioglu. Two findings of portal hypertension: Evaluation of correlation between serum-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis. Turk J Gastroenterol. 2003;14: 219-222.
M. Harputluoglu, U. Demirel, N. Karadag, I. Temel, M. Bayraktar, S. Firat, D. Karahan, M. Aladag, H. Alan, F. Ates, M. Karincaoglu, F. Hilmioglu. The effects of Gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats. Acta Gastroenterol. Document. 2006; 69:268-275.

Articles published in international refereed journals:
A1-Demirel, U. Karincaoglu, M., Harputluoğlu, M. M. M., Ates, M., Seckin, Y., Yildirim, B., Hilmioglu, F.,'' Two findings of portal hypertension: Evaluation of correlation between serum-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis'', Turk J Gastroenterol, 14, 219-222 (2003).

A2- Aladag, M., Kantarceken,B., Karıncaoglu, M., Sertkaya, A., Cıkım,K., Harputluoglu, M. M. M., Demirel,U., Alan, H., Ates, F., Yıldırım,B. , Hilmioglu, F., '' Comparison of pantoprazole- vs. omeprazole- based triple therapy regimens in treatment of Helicobacter pylori infection and duodenal ulcer healing in a Turkish population'', Turk J Gastroenterol, 16, 242-243 (2005).

A3- Harputluoglu, M., Demirel, U., Karadag, N., Temel, I., Bayraktar, M., Firat, S., Karahan, D., Aladag, M., Alan, H., Ates, F ., Karincaoglu, M., Hilmioglu, F.'' The effects of Gingko biloba, vitamin E and melatonin on bacterial translocation in thioacetamide-induced fulminant hepatic failure in rats'', Acta Gastroenterol. Belg, 69, 268-275 (2006).

A4- Harputluoglu, M., Demirel, U., Ciralik, H., Temel, I., Firat, S., Ara, C., Aladag, M., Karincaoglu, M., Hilmioglu, F, '' Protective effects of Gingko biloba on thioacetamid-induced fulminant hepatic failure in rats'', Hum. Exp. Tox, 25, 705-713 (2006).

A5- Ates, F., Topal, E., Kosar, F., Karincaoglu, M., Yildirim, B., Aksoy, Y., Aladag, M., Harputluoglu, M., Demirel, U., Alan, H. ., Hilmioglu, F, ''The relationship of heart rate variability with severity and prognosis of heart rate'', Dig. External. Sci, 51, 1614-1618 (2006).

A6- M. Harputluoglu, U Demirel, N. Yücel, N. Karadag, I. Temel, S. Fırat, C. Ara, M. Aladag, M. Karıncaoglu, F. Hilmioglu, '' The effects of Gingko biloba extract on acetic acid-induced colitis in rats'', Turk J Gastroenterol, 17, 177-182 (2006).

A7- M. Harputluoglu, U. Demirel, N. Karadag, D. Karahan, M. Aladag, M. Karıncaoglu, F. Hilmioglu, '' Severe hepatitis with prolonged cholestasis and bile duct injury: due the long-term use of ornidazole '', Acta Gastroenterol. Belg, 70, 293-295 (2007).

A8- M. Harputluoglu, U. Demirel, H. Alan, F. Ates, M. Aladag, M. Karincaoglu, F. Hilmioglu, ''Pancreatic pseudocyst development due to organophosphate poisoning'', Turk J Gastroenterol, 18, 122- 125 (2007).

A9. Y. Seckin, S. Arici, M. Harputluoglu, O. Yonem, A. Yilmaz, H. Ozer, M. Karincaoglu, U. Demirel, ''Expression of claudin-4 and beta-catenin in gastric premalignant lesions.'' , Acta Gastroenterol Belg, 72,407-12 (2009).

A10. I. Temel, U Demirel, M. Harputluoglu, Y. Seckin, M. Aladag, B. Otlu, N. Karadag, F. Ozyalin, N. Aydogan, E. B. Selcuk, '' Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats '', Turk J Gastroenterology, ( 2010).

A11. S. Aydin, I. Sahin, U. Demirel, A. Aksoy, ''To what extent is right to measure vaspin, obestatin and apelin-36 levels without a protease inhibitor in nonalcoholic fatty liver disease?'', Metabolism, doi: 10.1016/J.metabol.2011.01 015 (2011).

A12. U. Demirel, M. Harputluoglu, M. Yagmur, ''An Uncommon Presentation in Behcet's Disease: Recovered Descending-Colon Perforation with Conservative Medical Therapy: Case Report'', Turkiye Klinikleri Journal of Medical Sciences. 31(5),1310-1312 Doi:10.5336/medsci.2009-16000.

A13. U. Demirel, M. M. Harputluoglu, Y. Seckin, H. Ciralik, I. Temel, F. Ozyalin, B. Otlu, B. Yilmaz, M. S. Dincturk, H. Aladag, '', Hum Exp Toxicol, 30,560-566 (2011 ).

A14. U. Demirel, M. M. Harputluoglu, S. B. Us, E. Kaya, N. Sahin, N. E. Aydin, S. Gursoy, Y. Bilgic, M. Demirel, T. Bulut, E. B. Selcuk, M. Aladag, ''The effects of Teucrium polium on ionizing radiation-induced intestinal damage in rats.'' Acta Gastroenterol Belg,74(4), 491-496 (2011).

A15. M. Yalniz, U. Demirel, C. Orhan, I. H. Bahcecioglu, I. H. Ozercan, C. Aygun, M. Tuzcu, K. Sahin, ''Nadroparin Sodium Activates Nrf2/HO-1 Pathway in Acetic Acid-Induced Colitis in Rats. Inflammation’’, 2012 Feb 22. [Epub ahead of print]. PMID:22350949.

A16. M. Harputluoglu, U. Demirel, M. Gul, I. Temel, S. Gursoy, E. B. Selcuk, M. Aladag, Y. Bilgic, E. Gunduz, Y. Seckin. Effects of rifaximin on bacterial translocation in thioacetamide-induced liver injury in rats. Inflammation (2012).

A17. U. Demirel, M. Yalniz, C. Aygun, C. Orhan, M. Tuzcu, K. Sahin, I. H. Ozercan, I. H. Bahcecioglu, ''Allopurinol Ameliorates Thioacetamide Induced Acute Liver Failure by Regulating Cellular Redox Sensitive Transcription Factors in Rats'' , Inflammation, 2012 Apr DOI: 10. 1007/s10753-012-9470-5 (2012).

A18. Gokben Ozbey, Ulvi Demirel, Cem Aygun, "Investigation of the Association Between Clinical Outcome and the CAG Pathogenicity-island and Other Virulent Genes of Helicobacter Pylori Isolates From Dyspeptic Patients in Eastern Turkey”, Brazilian Journal of Microbiology, Acceptance letter is attached. (2014).

Papers presented at international scientific meetings and published in the proceedings:
B1. M. Aladag, M. Karincaoglu, B. Yildirim, M. Harputluoglu, M. Ates, M. Dikilitas, R. Yildiz, U. Demirel, F. Ates, H. Alan, F. Hilmioglu, Twelve-Month Combination Lam/ Inf-Alpha therapy induces a similar sustained response in anti-HBe positive and HBeAg-positive chronic hepatitis B patients. Proc. 12th UGW BMJ, 174, 53(suppl 6), Prague, 2004.

B2. M. Harputluoglu, N. Yücel, N. Karadag, I. Temel, S. Fırat, U. Demirel, M. N. Bayraktar, C. Ara, F. Hilmioglu. The effects of Gingko biloba extract(EGb 761) on the acetic-acid-induced colitis in rats. Oxtail. 147th Falk symposium. Colitis: Diagnosis and therapeutic strategies, Birmingham, 33, Falk Foundation, Freiburg, 2005.

B3. M. Aladag, M. Harputluoglu, C. Cicek, U. Demirel, K. Cikim, H. Alan, I. Öner, F. Ates, M. Karincaoglu, F. Hilmioglu. The effects of UDCA use in alkaline reflux gastritis. Proc. 147th Falk symposium. Colitis: Diagnosis and therapeutic strategies, Birmingham, 4, Falk Foundation, Freiburg, 2005

B4. C. Aygun, N. Gozel, U. Demirel, M. Yalniz, I. H. Bahcecioglu. Modifiable risk factors in chronic delta infection. Monothematic conference of The European Association For The Study of The Liver (EASL). September 24-26, Istanbul (Turkey), 2010.

Written international books or chapters in books:

Articles published in national refereed journals:
C1. I. Kuku, F. Ateş, E. Kaya, M. A. Erkurt, U. Demirel, A. Sevinç, İ. Aydoğdu, ''Use of Oral Vitamin B12 in Megalobalastic Anemias'', Clinical Development, 14,1-2 (2001).

C2. R. Sarı, U. Demirel, I. Sahin, I. Aydogdu, B. Mızrak, H. Taskapan, ''Myelodysplastic syndrome in an acromegaly patient: A case report'', Turk J Endocrinol. Metabol, 3,103-106 (2005).

C3. C. Aygun, N. Gözel, U. Demirel, M. Yalnız, İbrahim hanifi Özercan, İbrahim Halil Bahçecioğlu, ''The Relationship between Serum GGT Level and Liver Fibrosis in Patients Diagnosed with Chronic Viral Hepatitis B'', Fırat Medical Journal, 15(2) ), 74-78 (2010).

C4. M. Yalnız, M. Asoğlu, U. Demirel, C. Aygun, İbrahim Halil Bahçecioğlu, ''A case of hyperamylasemia: Macroamylasemia? ‘Review of the literature’, Journal of Clinical and Experimental Investigations, 2(1), 98-101 (2011).

C5. U. Demirel, I. H. Bahçecioğlu, ''Clinical Approach to Enteral and Parenteral Nutrition'', Current Gastroenterology, 14(3), 149-154 (2010).

C6. U. Demirel, I. H. Bahçecioğlu, ''The Relationship Between Irritable Bowel Syndrome and Inflammatory Bowel Disease'', Clinical Current Medicine Gastroenterology Forum, 3(1), 53-56 (2011).

C7. Cem Aygün, Ulvi Demirel, İbrahim Hanifi Özercan, Mehmet Ruhi Onur, Mehmet Yalnız, İbrahim Halil Bahçecioğlu,
,"A Case of Uveal Malignant Melanoma with Liver Metastasis After Radical Curative Surgical Resection: Letter to the Editor", Turkiye Klinikleri Journal of Gastroenterohepatology, issue 2 pp., 2011.

C8. Ulvi Demirel, Cem Aygün, "The Importance of the Nutritional Status of the Inpatient and Determination of Calorie Need", Fırat Medical Journal, 60-70, (2012).

C9. Ulvi Demirel, İbrahim Halil Bahçecioğlu, "Clinical Features in Inflammatory Bowel Diseases", Turkish Clinics Gastroenterohepatology Special Journal, issue 3 pp., (2012).

C10. Mehmet Yalnız, Ramazan Toksoy, Ulvi Demirel, Cem Aygün, Nevin İlhan, İbrahim Halil Bahçecioğlu, "Insulin resistance and adipocytokine in patients with acute pancreatitis", Academic Journal of Gastroenterology, 103-109, (2012).

Papers presented at national scientific meetings and published in proceedings:
E1. A. Sevinç, İ. Kuku, U. Demirel, F. Ateş, M. A. Erkurt, İ. Aydoğdu, H. Şavlı. Epistaxis due to isolated thrombocytopenia: Brucellosis. XXVII. National Hematology Congress, 158, Istanbul, 1999.

E2. I. Kuku, R. Sarı, A. Sevinç, F. Ateş, U. Demirel, İ. Aydoğdu. Oral high dose steroid treatment in ITP. XXVII. National Hematology Congress, 242, Istanbul, 1999.

E3. I. Kuku, A. Sevinç, U. Demirel, İ. Aydoğdu. Acute myeloblastic leukemia following Fanconi anemia: Two case reports. XXVII. National Hematology Congress, 140, Istanbul, 1999.

E4. A. Sevinç, İ. Kuku, F. Ateş, U. Demirel, İ. Aydoğdu, H. Şavlı, E. Aydin,. Paroxysmal nocturnal hemoglobinuria: Case report. XXVII. National Hematology Congress, 139, Istanbul, 1999.

E5. F. Ateş, M. A. Erkurt, İ. Kuku, U. Demirel. Oral vitamin B12 treatment in megaloblastic anemias due to vitamin B12 deficiency: Preliminary results. XXVII. National Hematology Congress, 138, Istanbul, 1999.

E6. A. Sevinç, İ. Kuku, U. Demirel, F. Ateş, M. A. Erkurt, B. Mızrak, İ. Aydoğdu, H. Şavlı. Burkitt Lymphoma: case report. XXVII. National Hematology Congress, 115, Istanbul, 1999.

Resume Update Date 09.09.2024